High-throughput 96-well cocrystal screening workflow for active pharmaceutical ingredients

Increasingly, poorly soluble drug candidates are entering development, which has made identifying and selecting stable solid forms of an active pharmaceutical ingredient (API) with enhanced in vivo absorption more difficult. While pharmaceutical salts are the most common choice for solid forms, cocrystals are also known to improve “druggability” characteristics such as solubility, dissolution, bioavailability and hydration stability. In addition, cocrystals have advantages in terms of their structure diversity and the potential for intellectual property protection.